Covid-19: Eight in 10 doctors have experienced moral distress during pandemic, BMA survey finds

Connectomes derived from volume EM imaging of the brain can generate detailed physical models every neuron, and simulators such as NEURON or GENESIS are designed to work with models. In principal, combining these technologies, plus transmitter channel models, should allow accurate simulation real neural circuits. Here we experiment this combination, using a well-studied system (motion detection in Drosophila). Since requires both geometry (which have) synapses not currently available), built approximate corresponding their known estimated function. Once did so, reproduced direction selectivity T4 cells, one main functions circuit. This verified basic functionality extraction simulations, provided biologically relevant computation could use further experiments. We then compared different degrees realism, full down consisting single node, examine tradeoff resources required versus accuracy achieved. Our results show that much simpler may be adequate, at least case medulla neurons Drosophila. Such easily fully result simulations smaller, faster, enough for many purposes. Biologically, lumped neuron model reproduces motion detector operation, confirming Gruntman[1], dendritic compution is